I would like to announce the following collaborative article, that was published recently in journal of infectious diseases.
“In vivo Prediction of Tuberculosis Cavity Formation in Rabbits“,
Journal of Infectious Diseases, Oxford University Press.
Volume 211, Issue 3, pp. 481-485, 2015. Impact Factor of the JID: 5.997
Brian Luna, André Kubler, Christer Larsson, Brent Foster, Ulas Bagci, Daniel J. Mollura, Sanjay Jain and William R. Bishai
Presence of cavitary lesions in tuberculosis patients poses a significant clinical concern due to the risk of infectivity and also due to the risk of antibiotic treatment failure. We describe 2 algorithms using non-invasive PET/CT imaging to predict the development of cavitary lesions in rabbits. Analysis of the PET region of interest predicted cavitary disease with 100% sensitivity and 76% specificity and analysis of the CT region of interested predicted cavitary disease with 83.3% sensitivity and 76.9% specificity. Our results show that restricting our analysis to regions with high [18F]-FDG uptake provided the best combination of sensitivity and specificity.
PDF of the paper is HERE.
Supplementary file is HERE.