Recently, I have read an article published in the New England Journal of Medicine (2010 impact factor is 53.48) showing the correlation of lung volumes and emphysema in smokers with the interstitial lung abnormalities. Here is the full link of the article provided by the first author of the article (G.R. Washko) :
In the study, linear and logistic regressions (for complex patterns it is usually not good enough to use simple linear regressions to find underlying complex relationships) are used to evaluate the associations between interstitial lung abnormalities and HRCT measurements of total lung capacity and emphysema. Findings show that in smokers, interstitial lung abnormalities were associated with reduced total lung capacity and a lesser amount of emphysema.
It is also worth noting that the effect of interstitial lung abnormalities on total lung capacity and emphysema was dependent upon chronic obstructive pulmonary disease (COPD) status. Interstitial lung abnormalities are positively associated with both greater exposure to tobacco smoke and current smoking.